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目的探讨阿托伐他汀对冠心病高脂血症及血管内皮功能的临床研究。方法2008年1月—2009年1月门诊或住院冠心病并高脂血症患者426例,常规剂量组226例采用阿托伐他汀10mg 1次/d;大剂量组200例:阿托伐他汀20mg,1次/d。两组均连续服用药物4周。观察肱动脉流量介导性舒张(FMD)功能检测、血清总胆固醇(TC)、血清甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及临床疗效。结果两组与治疗前进行观察内容经统计学比较P<0.01有显著差异性。常规剂量组治疗后与大剂量组治疗后经统计学比较P<0.05有显著差异性。两组临床疗效总有效率比较P<0.05有显著差异性。结论临床应用中应用较大剂量的阿托伐汀更能够有效的达到治疗目的,有效降低高血脂和改善血管内皮功能,防止冠心病的发展,起的良好的效果。
Objective To investigate the clinical study of atorvastatin on coronary heart disease with hyperlipidemia and vascular endothelial function. Methods From January 2008 to January 2009, 426 outpatients or hospitalized patients with coronary heart disease and hyperlipidemia were treated with atorvastatin 10 mg once daily for 226 patients in the conventional dosage group and 200 patients in the high dosage group (atorvastatin 20mg, 1 time / d. Both groups took the medication for 4 weeks continuously. (FMD), serum total cholesterol (TC), serum triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL- And clinical efficacy. Results The two groups were observed before treatment by statistical comparison P <0.01 significant difference. Conventional dose group after treatment with high-dose group after treatment by statistical comparison P <0.05 significant difference. The total effective rate of two groups compared P <0.05 significant difference. Conclusions Atropvastatin, which is used in larger doses in clinical practice, can effectively achieve therapeutic purposes, effectively reduce hyperlipidemia and improve endothelial function, and prevent the development of coronary heart disease.