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目的分析胎膜早破时间与血清C反应蛋白水平的关系及对绒毛膜羊膜炎发生率的影响。方法选择2011年5月-2014年10月发生胎膜早破患者132例,依据胎膜早破时间分为长程组(胎膜早破时间≥12h)68例和短时组(胎膜早破时间<12h)64例,入院后给予双抗体夹心酶联免疫吸附法测定C反应蛋白(CRP),比较2组患者血清CRP水平差异,采用Pearsman相关系数分析胎膜早破时间(h)与血清CRP水平之间相关性。入组患者产后均行胎膜病理检查,确定并比较2组患者组织学绒毛膜羊膜炎发生率。结果长程组患者血清C反应蛋白水平为(14.82±3.27)mg/L高于短时组的(6.39±1.48)mg/L,差异有统计学意义(P<0.05)。胎膜早破时间(t)与血清CRP水平之间呈直线正相关(r=0.674,P<0.05)。长程组组织学绒毛膜羊膜炎发生率为41.18%(28/68)高于短时组26.56%(17/64),差异有统计学意义(P<0.05)。结论胎膜早破时间与血清C反应蛋白水平之间存在一定相关性。胎膜早破时间越长,绒毛膜羊膜炎发生率越增加。
Objective To analyze the relationship between the time of premature rupture of membranes and the level of serum C-reactive protein and the influence on the incidence of chorioamnionitis. Methods 132 cases of premature rupture of membranes were selected from May 2011 to October 2014. According to the time of premature rupture of membranes, 68 cases were divided into long-term group (premature rupture of membranes≥12h) and short-term group (premature rupture of membranes Time <12h). After admission, C reactive protein (CRP) was measured by sandwich enzyme-linked immunosorbent assay (ELISA). The difference of serum CRP levels was compared between the two groups. Pearsman correlation coefficient was used to analyze the relationship between premature rupture of membranes CRP levels between the correlation. All patients were enrolled in prenatal fetal line pathological examination to determine and compare the incidence of histological chorioamnionitis in two groups. Results The level of serum C - reactive protein in the long - term group was (14.82 ± 3.27) mg / L, higher than that in the short - term group (6.39 ± 1.48) mg / L, the difference was statistically significant (P <0.05). Premature rupture of membranes (t) and serum CRP levels showed a linear correlation (r = 0.674, P <0.05). Long-term histological chorioamnionitis incidence was 41.18% (28/68) higher than the short-term group 26.56% (17/64), the difference was statistically significant (P <0.05). Conclusion There is a certain correlation between premature rupture of membranes and serum C-reactive protein level. The longer the premature rupture of membranes, the higher the incidence of chorioamnionitis.