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采用比色分析法对肝病患者血清芳香酯酶活性、高密度脂蛋白胆固醇、载脂蛋白Ａ１及一些肝功能指标进行了测定。结果：①与正常对照组相比，急性肝炎、慢性肝炎、肝硬化和肝癌患者血清芳香酯酶活性明显降低；②慢性活动性肝炎与慢性迁延性肝炎，失代偿性和代偿性肝硬化、慢性肝炎和肝硬化病例间酶活性有显著性差异，而肝硬化和肝癌患者间无差异；③血清芳香酯酶活性变化和总蛋白、白蛋白、载脂蛋白Ａ１、高密度脂蛋白及γ谷氨酰转移酶呈正相关，与丙氨酸氨基转移酶、碱性磷酸酶活性无相关；④芳香酯酶活性在各型肝病中降低幅度大于其他几项指标。提示：检测血清芳香酯酶活性可作为诊断与鉴别诊断各型肝病的参考指标，对肝细胞是否存在活动性的损害与其合成功能有无障碍有一定临床价值
Colorimetric analysis of serum aromatase esterase activity, high density lipoprotein cholesterol, apolipoprotein A1 and some liver function indicators were measured in patients with liver disease. Results: ①Compared with normal control group, serum aromatase activity was significantly decreased in patients with acute hepatitis, chronic hepatitis, cirrhosis and liver cancer; ② Chronic active hepatitis was associated with chronic persistent hepatitis, decompensated and compensated cirrhosis , There was a significant difference between the cases of chronic hepatitis and cirrhosis, but no difference between patients with cirrhosis and liver cancer. (3) The changes of serum aromatase esterase and total protein, albumin, apolipoprotein A1, high density lipoprotein and γ Glutamyl transferase was positively correlated with alanine aminotransferase, alkaline phosphatase activity was not related; ④ aromatase esterase activity in various types of liver disease decreased more than several other indicators. Tip: detection of serum aromatase esterase activity can be used as a diagnostic and differential diagnosis of various types of liver disease, a reference index of the existence of active liver cell damage and its synthetic function has some clinical value