应用组织病理学的方法。比较了各发育期日本血吸虫对吡喹酮作用的敏感性。结果表明:一次口服该药400mg/kg所引起的血吸虫皮层损害,以d_0(3h)童虫及d_(28～42)成虫为最严重;宿主的细胞反应也较强烈,并以中性粒细胞居多。而对d_(3～14)童虫则无或仅有轻微的皮层损害,宿主细胞反应亦较轻,且以淋巴细胞为主.d_(21)的童虫,虽有较为明显的皮层损害及宿主细胞反应,但细胞的类型与d_(3～14)童虫的相似. Apply histopathological methods. The sensitivity of schistosoma japonicum to praziquantel at different developmental stages was compared. The results showed that the cortical damage of schistosomiasis caused by the oral administration of 400mg / kg of the drug was the most serious in d_0 (3h) and d_ (28 ~ 42) adults. The host cell response was also more severe. Neutrophils Mostly. However, there was no or only mild cortical damage to d_ (3 ~ 14), and the host cell response was also mild with lymphocyte predominance. Although there was obvious cortical damage in d_ (21) The host cells reacted but the cell types were similar to those of d_ (3 ~ 14).