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目的:采用定量指纹图谱对醒脑通络注射液成品中的氨基酸成分进行控制,以此来评价其产品的质量。方法:采用AccQ Tag柱前衍生的方法,建立醒脑通络注射液中氨基酸成分的定量指纹图谱方法,对10批醒脑通络注射液中的各氨基酸进行定量检测,并结合10批成品的相似度指标,综合评价其质量。结果:醒脑通络注射液中含有12种氨基酸,各氨基酸特征峰定量结果均一、稳定,10批成品指纹图谱相似度在0.90以上。结论:该方法准确、可行,是一种简便、有效的中药质量评价手段。
OBJECTIVE: To evaluate the quality of its products by using quantitative fingerprinting to control the amino acid composition in Xingnao Tongluo Injection. Methods: Quantitative fingerprint of amino acids in Xingnao Tongluo Injection was established by AccQ Tag method. The amino acids in 10 batches of Xingnaotongluo injection were quantitatively detected. Similarity index, a comprehensive evaluation of its quality. Results: Xingnao Tongluo injection contained 12 kinds of amino acids, and the quantitative results of each amino acid peak were uniform and stable. The fingerprint similarity of 10 batches of finished products was above 0.90. Conclusion: This method is accurate and feasible, which is a simple and effective method for quality evaluation of traditional Chinese medicine.