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为了探讨山茱萸补肾阳作用,复制氢化考的松致肾阳虚动物模型,观察山茱萸水溶性总提取物对肾阳虚大鼠的影响。结果山茱萸水溶性总提取物能够提高肾阳虚大鼠的存活率和生命质量。其中大剂量组的存活率为73.30％,明显高于中剂量组(46.67％)、小剂量组、模型阳性药组和模型空白对照组(均为26.67％,P均<0.05),投以大、中剂量的山茱萸水溶性总提取物,可以使肾阳虚模型动物肾上腺病理改变显著减轻(P<0.01)。说明山茱萸水溶性总提取物具有补益肾阳、保护肾阳虚动物模型肾上腺组织,提高肾阳虚模型生命质量的作用。
In order to investigate the effect of Hawthorn tonic kidney, animal model of hydrogen decoction-induced kidney-yang deficiency was duplicated to observe the effect of total water-soluble extract of Hawthorn on kidney-yang deficiency rat. Results Hawthorn water-soluble total extract can improve the survival rate and quality of life of kidney-yang deficiency rats. The survival rate of the high-dose group was 73.30%, which was significantly higher than that of the middle-dose group (46.67%), the low-dose group, the model positive drug group, and the model blank control group (all were 26.67%, P<0.05). The total water-soluble extract of Hawthorn and middle dose of Hawthorn can significantly reduce the adrenal pathological changes of the kidney-yang-deficient model animals (P<0.01). The results showed that the water-soluble total extract of Hawthorn had the effect of replenishing kidney yang and protecting the adrenal gland tissue of animal model with kidney-yang deficiency, and improving the quality of life of the kidney-yang deficiency model.