论文部分内容阅读
氟嗪酸的S型左旋同分异构体R3355是一个新的有广谱抗菌活性的喹诺酮类抗菌药。本文报道了用琼脂稀释法测定临床分离病原菌的体外抗菌活性。结果表明,DR-3355对许多革蓝氏阳性和阴性菌的抗菌活性比氟嗪酸强2倍,其中对革蓝氏阳性需氧菌和厌氧菌、尤其是葡萄球菌属、脆弱拟杆菌和消化链球菌的活性,本品比氟嗪酸、丙氟哌酸、fleroxacin和NY-198强2～8倍,DR-3355对耐药葡萄球菌有很好的抗菌活性。本品对革蓝氏阴性菌的活性比丙氟哌酸稍弱、DR-3355对肺炎链球菌、化脓性链球菌和肠球菌的活性与丙氟哌酸相似,但比氟嗪酸、fleroxacin和NY-198强2～8倍,本品对肠
The sigmoidomer R3355 of trifluoperazine is a new quinolone antibacterial with broad spectrum antibacterial activity. In this paper, the in vitro antibacterial activity of clinically isolated pathogens was assayed by agar dilution method. The results showed that the antibacterial activity of DR-3355 against many Gram-positive and -negative bacteria is 2 times stronger than that of triflumuron, especially against Gram-positive aerobic and anaerobic bacteria, especially Staphylococcus, Bacteroides fragilis and The activity of Peptostreptococcus, this product is 2 to 8 times stronger than flufenamic acid, propoxyprofen, fleroxacin and NY-198, and DR-3355 has good antibacterial activity against drug-resistant Staphylococcus aureus. This product is slightly weaker against gram-negative bacteria than c-norfloxacin, DR-3355 has similar activity to ciprofloxacin against S. pneumoniae, S. pyogenes and enterococci, but is more active than clozapine, fleroxacin and NY-198 strong 2 to 8 times, the product of the intestine