脑缺血时脑组织间液(细胞外液)中的神经介质类氨基酸及腺苷均显著增多。兴奋性氨基酸可加剧脑缺血损伤,而抑制性氨基酸可拮抗兴奋性氨基酸的神经毒性作用。腺苷对氨基酸的释放有调节作用。本文就氨基酸和腺苷与脑缺血的关系,及其它们在脑缺血损伤中的作用等方面进行综述。 Cerebral ischemia in brain tissue fluid (extracellular fluid) in the neurotransmitter amino acids and adenosine were significantly increased. Excitatory amino acids can aggravate cerebral ischemic injury, while inhibitory amino acids can antagonize the excitatory amino acid neurotoxic effects. Adenosine on the release of amino acids have a regulatory role. This article reviews the relationship between amino acids and adenosine and cerebral ischemia, and their role in cerebral ischemia injury and other aspects.