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TGF-βRII基因突变会丧失对细胞生长和分化的调节,使细胞向癌变发展。hMSH6基因的突变会造成复制后错配修复功能丧失、整个基因组的不稳定、产生突变体,增加肿瘤易感性。本文就国内外对TGF-βRII/hMSH6与结直肠癌发生发展关系的研究进展作一综述。
TGF-βRII gene mutations will lose the regulation of cell growth and differentiation, so that cells to cancer development. Mutations in the hMSH6 gene result in a loss of function of the mismatch repair after replication. The entire genome is unstable, producing mutants and increasing tumor susceptibility. This review summarizes the research progress on the relationship between TGF-βRII / hMSH6 and the development of colorectal cancer at home and abroad.