Pseudorotaxane monomer (VBCB) containing cucurbitutil[6] (CB[6]) and N1-(4-vinylbenzyl)-1,4-diaminobutane dihydrochloride (VBDADC) is obtained by self-assembly of cucurbituril[6] with VBDADC in water and then polymerized using potassium persulfate (KPS) as initiator to give novel water-soluble side-chain cucurbituril[6]-based pseudopolyr1o taxane (PVBCB). The chemical structures of PVBCB, VBCB and VBDADC are confirmed by H NMR,13C NMR spectra and elemental analysis. In VBCB, CB[6] is localized aliphatic group of the side chain and the molar ratio of CB[6] to VBDAC is 1:1.