【摘 要】
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Epithelial-mesenchymal transition (EMT) is initially considered as a physiological phenomenon during the embryogenesis of mammals,as well as a basic biological
【机 构】
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Cancer Center,Renmin Hospital of Wuhan University,Wuhan 430060,China
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Epithelial-mesenchymal transition (EMT) is initially considered as a physiological phenomenon during the embryogenesis of mammals,as well as a basic biological event maintaining the stability of the vital body.Recent researches indicated that EMT plays a critical role in various tumors progression,through which epithelial cancers invade and metastasize.The cell characteristics are changed during EMT,in which the cells lose cell-cell and cell-matrix interactions and apical polarity,reorganize their cytoskeleton,and become isolated,motile,as well as resistant to anoikis,then become spindle-shaped mesenchymal cells.This review lays emphasis on studying the cell morphogenesis,makers and molecular mechanism regulation about EMT,discussing the relationship between the EMT and the cancer development and metastasis.
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