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目的 :探讨内皮素 (ET)和降钙素基因相关肽 (CGRP)在脑梗塞发病中的意义。方法 :采用放射免疫法 (RIA ) ,对 3 2例脑梗塞患者急性期和恢复期肘静脉血 ET和CGRP含量进行测定 ,并与 3 2例正常人进行对照。结果 :脑梗塞患者急性期血浆 ET含量明显增高 ,与对照组相比有非常显著性差异 ,恢复期较急性期明显下降 ,与对照组相比无差异 ,并且中重型患者 ET含量高于轻型。而 CGRP在脑梗塞急性期含量明显下降 ,与对照组比较有显著性差异 ,恢复期 CGRP明显增高 ,与对照组相比无差异 ,中重型患者 CGRP血浆含量明显低于轻型。结论 :ET和 CGRP参与脑梗塞的发病过程 ;测定 ET和 CGRP含量对急性脑梗塞的病情判断和临床分期有指导意义 ;维持 ET和 CGRP之间的平衡可能为脑梗塞治疗提供一条新的途径
Objective: To investigate the significance of endothelin (ET) and calcitonin gene related peptide (CGRP) in the pathogenesis of cerebral infarction. Methods: Radioimmunoassay (RIA) was used to measure the contents of ET and CGRP in the elbow venous blood in 32 acute cerebral infarction patients and in convalescent patients, and compared with 32 normal controls. Results: The levels of plasma ET in patients with acute cerebral infarction were significantly higher than those in the control group. The recovery period was significantly lower than that in the acute phase. There was no difference between the two groups. The ET level was higher in moderate and severe patients than in the control group. However, the content of CGRP in the acute phase of cerebral infarction decreased obviously compared with the control group, and CGRP in convalescent phase was significantly higher than that in control group. The content of plasma CGRP in moderate and severe patients was significantly lower than that in control group. Conclusions: ET and CGRP are involved in the pathogenesis of cerebral infarction. Determination of ET and CGRP levels may be helpful in judging the clinical stage and clinical stage of acute cerebral infarction. Maintaining the balance between ET and CGRP may provide a new approach for the treatment of cerebral infarction