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目的 为研究上皮钙粘附素 (E-CD)与人胃癌细胞分化程度、侵袭性、胃癌病期及预后的关系。 方法 应用免疫组化SP法对103例胃癌患者的手术切除标本及10例正常胃粘膜组织切片进行检测 ,并对其中60例胃癌术后患者进行随访 (随访期7～67个月 ,中位时间36.5个月 )。结果 (1)E -CD在正常胃粘膜上皮呈强表达 ,而在胃癌组织中56.3% (58/103)呈弱表达、18.4% (19/103)不表达。 (2)E -CD表达与胃癌细胞分化程度明显相关 (P=0.011) ;而与胃癌浸润深度、TNM分期、周围淋巴结转移程度、脉管存在癌栓与否、Borrmann分型及是否伴有远处转移无关 (均P>0.05)。(3)E -CD表达与胃癌患者术后生存率无关 (P>0.05)。结论 E-CD的存在与否可能决定胃癌细胞的分化程度 ,而对评估胃癌预后的价值可能不大
Objective To study the relationship between the expression of E-cadherin (E-CD) and human gastric cancer cell differentiation, invasion, stage of gastric cancer and its prognosis. Methods The immunohistochemical SP method was used to detect the specimens of 103 cases of gastric cancer and 10 cases of normal gastric mucosa. The follow-up of 60 cases of postoperative patients with gastric cancer (follow-up period of 7 to 67 months, median time 36.5 months). Results (1) E-CD was strongly expressed in normal gastric mucosa epithelium, while 56.3% (58/103) was weakly expressed in gastric cancer tissue, while 18.4% (19/103) was not expressed in gastric mucosa. (2) The expression of E-CD was significantly correlated with the degree of differentiation of gastric cancer cells (P = 0.011), but not with the depth of invasion of gastric cancer, TNM stage, degree of lymph node metastasis, tumor embolism in vessels, Borrmann type, There was no relationship between metastasis (all P> 0.05). (3) E-CD expression had no correlation with postoperative survival rate of gastric cancer patients (P> 0.05). Conclusion The presence or absence of E-CD may determine the degree of differentiation of gastric cancer cells and may not be of value in assessing the prognosis of gastric cancer