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本研究动态检测了益肾健脾中药对老年虚证的Ｔ细胞亚群、可溶性白细胞介素－２受体（ＳＩＬ－２）及红细胞免疫等指标的影响，并以健康献血员为对照。结果：老年虚证组Ｔ淋巴细胞亚群ＣＤ_３、ＣＤ_４显著降低，ＣＤ_８显著增加，故ＣＤ_４／ＣＤ_８显著下降（Ｐ＜０．０１）；ＳＩＬ－２Ｒ显著增高（Ｐ＜０．０１）；红细胞免疫指标红细胞Ｃ_３ｂ受体花环率（ＲＢＣ－Ｃ_３ｂＲＲ）显著降低，红细胞免疫复合物花环率（ＲＢＣ－ＩＣＲ）增高（Ｐ＜０．０１）。进而分析发现老年虚证组ＣＤ_４／ＣＤ_８与ＳＩＬ－２Ｒ呈负相关（ｒ＝－０．５７２，Ｐ＜０．０１），而与ＲＢＣ－Ｃ_３ｂＲＲ呈正相关（ｒ＝０．４３５，Ｐ＜０．０２）。经益肾健脾治疗后，虚象减轻，免疫指标改善，呈相对应负性改变（Ｐ＜０．０１与Ｐ＜０．０５），但与正常对照比较，除红细胞免疫指标接近正常外，其余仍低于正常（Ｐ＜０．０１），且上述相关性消失。提示益肾健脾对免疫功能有显著改善作用，但仍低于正常。
This study dynamically detected the effects of yishenjianpi herbs on T-cell subsets, soluble interleukin-2 receptor (SIL-2), and red blood cell immunity in elderly patients with deficiency syndromes, and compared them with healthy blood donors. RESULTS: The CD3 and CD4 levels of the T-lymphocyte subsets in the elderly deficiency group were significantly decreased, and the CD8 was significantly increased. Therefore, the CD4/CD8 ratio was significantly decreased (P<0.01); the SIL-2R was significantly higher (P<0.01); The red blood cell C_3b receptor rosette rate (RBC-C_3bRR) was significantly decreased, and the red blood cell immune complex rosette rate (RBC-ICR) was increased (P<0.01). Further analysis revealed that CD_4/CD_8 was negatively correlated with SIL-2R in the elderly deficiency syndrome group (r=-0.572, P<0.01), but positively correlated with RBC-C_3bRR (r=0.435, P<0. 02). After treatment with yin and spleen, the imaginary image was relieved and the immune index was improved, showing a corresponding negative change (P<0.01 and P<0.05). However, compared with the normal control, except that the red blood cell immune index was close to normal, The rest was still lower than normal (P < 0.01), and the above correlation disappeared. It suggests that replenishing kidney and spleen has a significant improvement in immune function, but it is still lower than normal.