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目的：观察不同剂量氦氖激光照射豚鼠表皮郎格尔汉斯细胞后对其抗原提呈功能的影响。方法：用耳肿试验和同种异体表皮淋巴细胞混合培养反应方法观察氦氖激光照射对豚鼠表皮郎格尔汉斯细胞抗原提呈功能的影响。结果：在耳肿试验中，１．１６Ｊ／ｃｍ２，２．３２Ｊ／ｃｍ２和４．６５Ｊ／ｃｍ２剂量均增加豚鼠的耳叶厚度，以２．３２Ｊ／ｃｍ２最显著。在同种异体表皮淋巴细胞混合培养反应中，０．５９Ｊ／ｃｍ２，１．１９Ｊ／ｃｍ２和２．３７Ｊ／ｃｍ２剂量均增强郎格尔汉斯细胞刺激Ｔ细胞增殖的能力。结论：一定剂量的低能量氦氖激光照射可增强郎尔汉斯细胞的抗原提呈功能
OBJECTIVE: To observe the effect of different doses of He-Ne laser irradiation on antigen presenting function of Langerhans cells in guinea pig epidermis. Methods: The effects of He-Ne laser irradiation on the antigen presenting function of Langerhans cells in the epidermis of guinea pigs were observed by the ear test and the mixed culture of allogeneic epidermal lymphocytes. Results: In the ear test, 1.16J / cm2,2.32J / cm2 and 4.65J / cm2 doses increased the thickness of the guinea pig’s ear, which was the most significant at 2.32J / cm2. In allogeneic epidermal lymphocyte mixed culture reaction, 0.59J / cm2, 1.19J / cm2 and 2.37J / cm2 dose all enhanced the ability of Langerhans cells to stimulate T cell proliferation. Conclusion: A dose of low-energy He-Ne laser can enhance the antigen presenting function of Langerhans cells