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目的 探讨提高膀胱癌的治疗效果 ,降低术后复发率的更佳膀胱内灌注方案。方法 将42例行经尿道膀胱肿瘤电切术 (TURBt)的浅表性膀胱癌分为两组 :A组 (21例 )膀胱内灌注丝裂霉素加卡介苗素 ,B组 (21例 )膀胱内单纯灌注丝裂霉素。两组均在术后1周内开始灌注 ,每周1次 ,共6次 ,然后每月1次 ,共2年。 结果 随访12～28个月 ,A组复发1例 ,复发率4.8% ,B组复发7例 ,复发率33.3% ,两组复发率的并别有显著性意义 (P<0.05)。 结论 丝裂霉素C加卡介苗素膀胱内灌注能明显减少膀胱癌的术后复发
Objective To explore a better intravesical instillation scheme to improve the curative effect of bladder cancer and reduce the postoperative recurrence rate. Methods 42 cases of TURBt superficial bladder cancer were divided into two groups: group A (21 cases) intravesical instillation of mitomycin plus BCG, group B (21 cases) bladder Within a simple infusion of mitomycin. Both groups started perfusion within 1 week after surgery, once a week for 6 times and then once a month for 2 years. Results The patients were followed up for 12 to 28 months. Recurrence rate was 4.8% in group A and 7 in group B. The recurrence rate was 33.3%. There was no significant difference between the two groups (P <0.05). Conclusion Mitomycin C plus BCG infusion can significantly reduce the postoperative recurrence of bladder cancer