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目的:总结CD44分子与胃癌临床病理特征及预后的关系,探讨CD44基因在胃癌发生发展中的作用。方法:应用PubMed及CNKI全文数据库检索系统,以“CD44、胃癌和肿瘤干细胞”等为关键词,检索2003-01-2012-07的相关文献,共检索到45篇文献,其中英文41篇,中文4篇。文献纳入标准:1)CD44分子的生物学特性;2)CD44与肿瘤干细胞的关系;3)CD44与胃癌发生、临床病理特征及患者预后的关系。根据纳入标准,符合分析的文献33篇。结果:CD44+细胞具有自我更新、多向分化、克隆球形成及体内成瘤等肿瘤干细胞/肿瘤起始细胞特性。CD44分子在胃癌组织的表达量显著高于癌旁正常组织,其表达水平越高,癌肿浸润越深,转移概率越大,患者预后越差,并与胃癌的组织类型具有相关性。结论:CD44能够介导胃癌的发生,促进癌细胞的侵袭和转移,其阳性表达影响患者预后,可能会为胃癌的早期诊断和靶向治疗提供新的科学依据。
OBJECTIVE: To summarize the relationship between CD44 and the clinicopathological characteristics and prognosis of gastric cancer, and to explore the role of CD44 in the occurrence and development of gastric cancer. Methods: PubMed and CNKI full-text database retrieval system was used to search the related literature of 2003-01-2012-07 with “CD44, gastric cancer and cancer stem cells” as the key words, and 45 articles were retrieved, of which 41 were English , Chinese 4. Literature inclusion criteria: 1) biological characteristics of CD44 molecules; 2) the relationship between CD44 and tumor stem cells; 3) CD44 and gastric cancer, clinicopathological features and prognosis of patients. According to the inclusion criteria, 33 articles were analyzed. Results: The characteristics of CD44 + cells were self-renewal, multidirectional differentiation, spheres formation and in vivo tumorigenesis of tumor stem cells / tumor initiating cells. The expression of CD44 in gastric cancer tissue was significantly higher than that in adjacent normal tissues. The higher the expression level of CD44 was, the deeper the invasion of cancer was. The higher the probability of metastasis, the poorer the prognosis of patients was, and was correlated with the type of gastric cancer. Conclusion: CD44 can mediate the occurrence of gastric cancer and promote the invasion and metastasis of cancer cells. The positive expression of CD44 affects the prognosis of patients and may provide a new scientific basis for the early diagnosis and targeted therapy of gastric cancer.