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采用瑞氏染色、红细胞内外铁染色和受体的放射配体结合分析法,对29例16～28孕周胎儿肝脏与骨髓红细胞系统进行了比较研究.结果发现:(1)贮存铁在正常范围的胎儿的骨髓幼红细胞比例(42.8%)明显低于肝脏(84.4%),其变异系数均明显高于肝脏;(2)24～28周孕的胎儿,其肝脏的红细胞内、外铁均较骨髓为多;(3)骨髓幼红细胞转铁蛋白受体数量及其与配体的亲和力均明显低于肝脏;(4)母体发生缺铁性贫血时,虽然骨髓受体数量明显上升,但亲和力和幼红细胞比例仍低于肝脏.结果提示:28孕周以前,肝脏仍是红系造血的主要器官,骨髓造血的稳定性及代偿能力均受到生理发育的限制.
The Wistar rat’s staining, erythrocyte internal and external iron staining and receptor’s radioligand binding assay were used to compare the liver and bone marrow erythrocyte system in 29 fetuses from 16 to 28 gestational weeks. The results showed that: (1) iron storage was in the normal range (42.8%) of the fetuses were significantly lower than that of the liver (84.4%), and the coefficient of variation was significantly higher than that of the liver. (2) The fetuses from 24 to 28 weeks of gestation had more intrahepatic red blood cells Bone marrow and more; (3) the number of erythrocyte transferrin receptor in bone marrow and its affinity with the ligand were significantly lower than the liver; (4) the occurrence of iron deficiency anemia in the mother, although the number of bone marrow receptors increased significantly, but the affinity And erythrocyte ratio is still lower than the liver.The results suggest that: before 28 gestational weeks, the liver is still the major organ of erythroid hematopoiesis, the stability and compensatory ability of bone marrow hematopoiesis are limited by the physiological development.