抗胆碱能药物的全身吸收可能是药物引起老年人谵妄的一种机制,具有抗胆碱作用的药物与谵妄的关系比任何其他种类药物更为密切。老年人常服多种药物,其中有些已知有抗胆碱能作用,当这些药物联合使用时,很可能引起抗胆碱能中毒综合征。本文从老年人常用的25种药物中观察其抗胆碱能作用。方法:取老年人最常用的25种药物样品,然后用放射性抗胆碱能受体测定每种药标准浓度时的抗胆碱效应,把每种药稀释到10~(-8)克分子浓度,用硫酸阿托品原有的标准作对比,按统一的测量单位比较各种药物的稀释浓度,药物浓度可用相当于阿托品的纳 The systemic absorption of anticholinergic drugs may be a mechanism by which drugs cause delirium in the elderly, and anticholinergic drugs are more closely linked to delirium than any other drug. The elderly often take a variety of drugs, some of which are known to have anticholinergic effects, when used in combination with these drugs, is likely to cause anticholinergic syndrome. This article from the elderly commonly used 25 kinds of drugs to observe its anticholinergic effect. Methods: Take the 25 most commonly used drugs for the elderly, then measure the anticholinergic effect of each drug by radioactive anticholinergic receptor and dilute each drug to 10-8 mol concentration , With atropine sulfate as the original standard for comparison, according to a unified unit of measurement compared to the dilution of various drugs, the drug concentration can be equivalent to atropine Na