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目的:用BAYESIAN 反馈法估算头孢拉定在体外循环术后患儿的药动学参数,为临床应用提供依据.方法:采用HPLC法测定头孢拉定血药浓度.选择不同取样时间的1 个血药浓度作为反馈,用BAYESIAN 法估算个体药动学参数,并与经典药动学方法估算的结果比较.结果:二步法估算的群体药动学参数为,T1/2α 0－30 ±0－10H, T1/2β 3－08 ±1－68H, VC 0－24 ±－15L?KG－ 1, VD 1－09 ±0－57L?KG－1 , CL248－3±55－4ML?H－1?KG－1 .用1 个血药浓度反馈估算的药动学参数与经典药动学方法估算结果之间的差异无显著性.结论:用BAYESIAN 反馈法估算个体药动学参数及预测血药浓度,可满足临床优化个体化给药方案的需要“,”AIM To estimate individual pharmacokinetic parameters of cefradin in children after cardiopulmonary bypass by Bayesian approach.METHODS The serum concentrations of cefradin were measured by HPLC.Using 1 measured drug concentration,individual pharmacokinetic parameters were estimate by Bayesian feekback method and the parameters compared with parameters estimated by traditional method.RESULTS The population-average pharmacokinetic parameters with two step method were,T 1/2α 0 30±0 10h,T 1/2β 3 08±1 68h,Vc 0 24±0 15L·kg -1 ,Vd 1 09±0 57L·kg -1 ,Cl 248 3±55 4ml·h -1 ·kg -1 .The pharmacokinetic parameters estimated by Bayesian approach no have significant difference compared with those estimated by traditional method.CONCLUSION Bayesian approach is suitable for estimating individual pharmacokinetic parameters,forecasting plasma concentration and optimizing individualizing dosage regimens.