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目的:探讨米索前列醇与催产素用于晚期妊娠引产的效果。方法:将200例足月单胎头位的初产妇随机分为两组,米索组应用米索前列醇25μg塞于阴道后穹窿,软枕抬高臀部,平卧半小时,如无宫缩,间隔6 h后再次放置25μg,每天累计不超过50μg。催产素组予催产素2.5 U加入5%葡萄糖500 ml中以8滴·min-1速度开始静脉点滴,根据宫缩调整滴速,最快速度不超过30滴·min-1,如仍未临产,于次日再次宫颈评分,重新用药。结果:米索组引产成功率达98%,催产素组引产成功率68%,两者差异有统计学意义(P<0.001)。宫颈评分<7时,米索组引产成功率为91.7%,催产素组引产成功率为52.7%,两组差异也有统计学意义(P<0.001),结论:米索前列醇引产效果优于催产素,尤其在低宫颈评分(<7)中促宫颈成熟效果优于催产素,且用药是安全的。
Objective: To investigate the effect of misoprostol and oxytocin on induction of labor during late pregnancy. Methods: The 200 primiparae of full-term single head position were randomly divided into two groups. The misoprostol group was treated with misoprostol 25 μg in the posterior vaginal fornix. The soft pillow raised the buttocks for half an hour. If no contractions , After an interval of 6 h again placed 25μg, a total of not more than 50μg daily. Oxytocin group to oxytocin 2.5 U by adding 5% glucose 500 ml in 8 drops · min-1 speed start intravenous drip, according to the contractions adjust drip rate, the fastest speed of not more than 30 drops · min-1, such as still not yet produced Cervical score again on the next day, re-medication. Results: The success rate of misoprostol induction of labor was 98% and oxytocin induction rate of 68%, the difference was statistically significant (P <0.001). Cervical score <7, the success rate of misoprostol induction of labor was 91.7%, oxytocin induction rate of 52.7%, the difference between the two groups was also statistically significant (P <0.001), Conclusion: misoprostol induction of labor is better than oxytocin Uterine cervix maturation is superior to oxytocin, especially in the low cervical score (<7), and medication is safe.