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目的 回顾性评价稻栖黄单胞菌 (Flavimonasoryzihabitans)感染的临床特点和细胞免疫功能。方法 我们鉴定了我院自 1994年 11月至 1998年 12月稻栖黄单胞菌感染 11例 ,收集的相关资料包括稻栖黄单胞菌感染的临床表现、潜在的疾病及统计资料等 ,测定了 11株稻栖黄单胞菌对 15种抗菌素的体外药敏试验 ,利用流式细胞仪测定了外周血T细胞亚群 (CD3、CD4、CD8细胞数和CD4 /CD8比值 )和NK(CD16 +56 )细胞数。结果 本组稻栖黄单胞菌感染中男性 6例 ,女性 5例 ,平均年龄 4 7 6 4岁 (5- 6 9岁 )。除一例外所有病人有严重的潜在疾病 ,9(81 8% )例病人为医院内感染 ,2 (18 2 % )例病人为院外感染 (病例 2和 5) ;8(72 7% )例表现为原发性稻栖黄单胞菌血症 ,胸膜炎、软组织感染和腹膜炎各一例 ;所有菌株对丁胺卡那霉素、庆大霉素及环丙沙星敏感 ,而对头胞唑啉、呋喃坦啶和青霉素不敏感 ;CD3、CD4、CD4 /CD8和NK细胞值低于正常 (P <0 0 1) ;抗菌素治疗后体温≤ 37℃平均为 3 5天 (1- 6天 ) ,所有病人临床症状均消失和治愈。结论 稻栖黄单胞菌感染是临床上非常少见的病例 ,与潜在疾病和外来材料存在有关 ;免疫功能异常是引起稻栖黄单胞菌感染的主要因素之一。
Objective To retrospectively evaluate the clinical features and cellular immune function of Flavimonasoryzihabitans infection. Methods We identified 11 cases of X. choriophylla infection in our hospital from November 1994 to December 1998. The relevant data collected included the clinical manifestations, potential diseases and statistics of X. choriophila infection, The antibacterial activity of 15 antibiotics was tested in 11 strains of X. choriophila. The T lymphocyte subsets (CD3, CD4, CD8, CD4 / CD8) and NK CD16 +56) cells. Results In this group, 6 males and 5 females were infected with X. monocytogenes, with an average age of 476 years (range 5-9 years). Nine (81.8%) were all hospital-acquired infections, 2 (182%) were nosocomial infections (cases 2 and 5), and 8 (72.7%) were cases of serious underlying disease with one exception For the primary case of Xanthomonaspotxemia, pleurisy, soft tissue infections and peritonitis in each case; all strains sensitive to amikacin, gentamicin and ciprofloxacin, while the head of the oxazolidin, furan (P <0.01). After treatment with antibiotics, the average body temperature ≤ 37 ℃ was 35 days (1-6 days), and all patients were not sensitive to penicillin and penicillin. The levels of CD3, CD4, CD4 / CD8 and NK cells were lower than normal Clinical symptoms disappeared and healed. Conclusion Xanthomonas cholerae infection is a clinically very rare case, which is related to the underlying disease and the presence of foreign materials. Abnormal immune function is one of the main causes of X. chrysogenum infection.