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用地高辛素探针原位杂交技术研究52例慢性HBV感染者肝内HBV DNA分布,发现在病毒高复制期,HBV DNA阳性肝细胞以弥漫性分布为主,肝细胞HBV DNA表型为胞浆型和核型,在病毒低复制期肝内HBV DNA阳性肝细胞以小叶聚集分布为主,多分布于灶性坏死和碎片状坏死区,在病毒非复制期,HBV DNA阳性肝细胞以局灶性分布为主,表型多为包涵体型和核型。提示在漫长的HBV感染过程中,肝内HBV DNA阳性肝细胞的分布经历弥漫性—小叶聚集性—局灶性的演变过程,该过程反映肝组织内HBV的清除模式。HBeAg(+)的慢性HBV无症状感染者肝组织病变轻可能是由于HBV DNA易装配为完整的病毒排出肝细胞的结果。说明免疫活性细胞攻击的靶细胞主要是含有HBV DNA的肝细胞。
Using the digoxin probe in situ hybridization technique to study the distribution of HBV DNA in 52 patients with chronic HBV infection, we found that the distribution of HBV DNA positive hepatocytes was diffusely distributed and the hepatocyte HBV DNA phenotype was high Plasma type and karyotype. In the low replication phase, HBV DNA positive hepatocytes in the liver were mainly distributed in the lobules, mostly in focal necrosis and debris necrosis. In the non-replication phase, Focal distribution of the main phenotypic inclusions and karyotype. It is suggested that in the long process of HBV infection, the distribution of intrahepatic HBV DNA-positive hepatocytes undergo diffuse-lobular aggregation-focal process of evolution, which reflects the pattern of HBV clearance in liver tissue. Chronic liver HBV infection in patients with HBeAg (+) asymptomatic liver lesions may be due to HBV DNA easily assembled as a complete virus as a result of the discharge of hepatocytes. The target cells indicating that the immunocompetent cells attack are predominantly hepatocytes containing HBV DNA.