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天然来源抗肿瘤活性产物是抗肿瘤药物先导化合物的重要资源。促分裂原活化蛋白激酶(MAPK)通路是细胞内重要的信号转导系统,可以调节细胞的生长、凋亡、黏附、迁移等过程,继而影响肿瘤的发生、发展、侵袭、转移,是潜在的抗肿瘤药物作用靶点之一。本文将对天然来源化合物作用于MAPK信号通路的靶点分子及生物效应进行阐述,为肿瘤的化学预防及治疗提供启发。
Anti-tumor active products of natural origin are important resources for antitumor drug lead compounds. Mitogen-activated protein kinase (MAPK) pathway is an important intracellular signal transduction system, which can regulate cell growth, apoptosis, adhesion, migration and other processes, and then affect the occurrence, development, invasion and metastasis of tumors. It is potentially Antitumor drugs one of the targets. In this paper, the target molecules and biological effects of natural source compounds acting on the MAPK signaling pathway are expounded, providing inspiration for the chemoprevention and treatment of tumors.