论文部分内容阅读
帕利哌酮棕榈酸盐是一种非典型抗精神病药物的长效针剂,活性成分为帕利哌酮,也称9-羟利培酮,主要通过阻断5-羟色胺2A受体和多巴胺D2受体发挥抗精神病药作用。该药在制备过程中采用了特殊的纳米晶体技术,有效提高药物溶解度,使得药物在使用过程中更加安全有效。经试验证实,帕利哌酮棕榈酸盐对精神分裂症急性期治疗和维持治疗效果较好,与现有长效针剂相比具有一定优势,为精神分裂症患者的治疗提供了一种新的选择。
Paliperidone palmitate is an atypical antipsychotic long-acting injection with active ingredient Paliperidone, also known as 9-hydroxyrisperidin, mainly by blocking the serotonin 2A receptor and dopamine D2 Receptors play an antipsychotic effect. The drug in the preparation process using a special nanocrystal technology, effectively improve the drug solubility, making the drug more safe and effective during use. Experiments confirmed that paliperidone palmitate in the acute phase of schizophrenia treatment and maintenance of good treatment effect, compared with the existing long-acting injection has some advantages, for the treatment of schizophrenia provides a new select.