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目的:探讨超声量化技术评价大鼠肝脏脂肪变的价值。方法:大鼠ig酒精高脂乳液12周,制备脂肪肝模型。测量正常大鼠及模型大鼠肝脏二维声像图的灰度值,检测肝组织三酰甘油(TG)、总胆固醇(TC),并将肝脏组织做病理切片,观察肝细胞脂变情况。结果:与正常组比较,模型组超声图像近区、远区灰度显著增加,肝脏TG、TC明显升高。组织病理学分析可见模型大鼠肝脏典型脂肪样变。结论:超声量化技术可作为一种无创性量化方法用于判断大鼠肝脏脂肪变化。
Objective: To evaluate the value of ultrasound quantification in evaluating hepatic steatosis in rats. Methods: Rat ig alcohol-fat emulsion for 12 weeks to prepare fatty liver model. The gray value of liver two-dimensional sonography in normal rats and model rats was measured. The triglyceride (TG) and total cholesterol (TC) in liver tissues were detected. The liver tissues were made into pathological sections to observe the lipid changes of hepatocytes. Results: Compared with the normal group, the gray value of the near-far and far-field of the model group increased significantly and the TG and TC of the liver increased obviously. Histopathological analysis shows that typical fatty liver samples of rats. Conclusion: The ultrasound quantification technique can be used as a noninvasive quantitative method to determine the hepatic steatosis in rats.