１引言类风湿关节炎（rheumatoidarthritis，RA）是一种以关节慢性炎症为主要表现的自身免疫性疾病，并且是一种致残性疾病。尽管至今RA的病因尚未明确，但在过去１０年RA发病机制的研究已取得了较大的进展，并且带动了RA诊断与治疗的进展。除类风湿因子（RF）外，新的RA自身抗 1 Introduction Rheumatoid arthritis (RA) is an autoimmune disease mainly characterized by chronic inflammation of the joints and is a disabling disease. Although the etiology of RA has not yet been clarified, the research on the pathogenesis of RA has made great progress in the past 10 years, and has led to the progress of the diagnosis and treatment of RA. In addition to rheumatoid factor (RF), new RA autoantibodies