帕金森病(Parkinson s disease,PD)是常见的神经系统退行性变性疾病,病理特征是黑质内多巴胺能神经元变性损失和细胞浆出现路易小体。病因和发病机制还不明确,但普遍认为,PD并非单一因素所致,可能是遗传因素和环境因素共同作用的结果,氧化应激、线粒体功能障碍、泛素蛋白酶体系 Parkinson’s disease (PD) is a common degenerative disease of the nervous system. The pathological features are the loss of degeneration of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies in the cytoplasm. Etiology and pathogenesis is not yet clear, but it is generally believed that PD is not caused by a single factor, which may be the result of genetic and environmental factors together. Oxidative stress, mitochondrial dysfunction, ubiquitin protease system