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我科1987年遇到2例原用青霉素G钠盐,后改用氨苄青霉素及用不同批号氨苄青霉素引起过敏,报告如下。如1 陈某,男,69岁,慢性支气管炎急性发作,于1987年2月13日入院。入院后用10％葡萄糖液500ml加青霉素G钠盐4.8×10~6u静脉点滴。5天之后改用氨苄青霉素6.0g静脉点滴,约2h后,患者周身皮肤发痒,呼吸困难,BP13.3/8.0kPa(100/60mmHg),心率84min,背部及四肢散在充血皮疹。即停止输液,静注地塞米松5mg,口服强的松10mg、朴尔敏8mg,约0.5h后症状开始缓解。
Our department encountered two cases of original penicillin G sodium in 1987, then changed to ampicillin and ampicillin with different batches cause allergy, the report is as follows. Such as a Chen, male, 69 years old, acute exacerbation of chronic bronchitis, in February 13, 1987 admission. After admission with 10% glucose solution 500ml plus penicillin G sodium 4.8 × 10 ~ 6u intravenous drip. After 5 days, it was changed to ampicillin 6.0g intravenously. After about 2h, the skin of the patient was itchy and had dyspnea. BP13.3 / 8.0kPa (100 / 60mmHg), heart rate 84min, and rash on the back and extremities. That stop infusion, intravenous dexamethasone 5mg, oral prednisone 10mg, Pu Ermin 8mg, about 0.5h after the symptoms began to ease.