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目的 观察无痛负压吸宫术前应用米索前列醇的宫颈软化作用及药物不良反应的发生率。方法 选取无阴道分娩史、初次行无痛人工流产术患者180例,按就诊顺序随机分成3组,每组60例,A组单用异丙酚行无痛负压吸宫术,B组阴道后穹窿放置米索前列醇400μg,3小时后行异丙酚无痛负压吸宫术,C组口服米索前列醇400μg,3小时后行异丙酚无痛负压吸宫术。观察患者无痛效果、宫颈松弛情况、术中出血量、手术时间及药物不良反应(恶心、呕吐、腹痛、腹泻及术前阴道流血)。结果 宫颈松弛作用、麻醉效果B组和C组明显优于A组,且B组优于C组(P<0.05);B组药物不良反应、恶心、腹泻发生率明显低于C组(P<0.05)。结论 在无痛负压吸宫术前使用米索前列醇可有效松弛宫颈,提高异丙酚麻醉满意度。
Objective To observe the effect of misoprostol on cervix softening and adverse drug reactions before painless suction. Methods A total of 180 patients without painful vaginal delivery were enrolled in this study. They were randomly divided into 3 groups (60 in each group) according to the order of their visits. Group A received painless vacuum aspiration with propofol alone and Group B vagina After the posterior fornix placed 400μg misoprostol 3 hours after painless suction Palace, Group C oral misoprostol 400μg, 3 hours after the propofol painless vacuum aspiration. Pain relief, cervical relaxation, intraoperative blood loss, operative time and adverse drug reactions (nausea, vomiting, abdominal pain, diarrhea and preoperative vaginal bleeding) were observed. Results Cervical relaxation and anesthesia were significantly better in group B and group C than in group A, and group B was better than group C (P <0.05). The incidence of adverse drug reactions, nausea and diarrhea in group B was significantly lower than that in group C (P < 0.05). Conclusion The use of misoprostol before painless vacuum aspiration can effectively relax cervix and improve the satisfaction of propofol anesthesia.