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目的 探讨胱抑素C(serum Cystatin C,Cys C)在妊娠期高血压疾病(hypertensive disorders of pregnancy,HDP)早期肾损害的应用价值。方法 收集HDP患者和正常晚期妊娠孕妇血清,测定CysC、肌酐(serum creatinine,Scr)、尿酸(uric acid,UA)、尿素氮(Urea),计算肌酐清除率(creatinine clearance rate,CCr)。结果 ①Urea、Scr、UA、CCr水平,妊娠期高血压、轻度子痫前期及慢性高血压合并子痫前期3组与重度子痫前期及正常组比较差异有统计学意义(P<0.05),3组间比较差异无统计学意义(P>0.05);②CysC水平各组不同,组间比较均有统计学意义(P<0.05)。结论 血清CysC水平可敏感、准确地反映HDP患者早期肾损害。
Objective To investigate the value of serum Cystatin C (Cys C) in the early stage of renal damage in hypertensive disorders of pregnancy (HDP). Methods Serum samples from patients with HDP and normal pregnant women were collected. CysC, serum creatinine (Scr), uric acid (UA) and urea were measured and creatinine clearance rate (CCr) was calculated. Results ① There were significant differences in the levels of Urea, Scr, UA, CCr, gestational hypertension, mild preeclampsia and chronic hypertension with preeclampsia and severe preeclampsia and normal controls (P <0.05) There was no significant difference among the three groups (P> 0.05). (2) The levels of CysC were different in each group, with statistical significance (P <0.05). Conclusion The level of serum CysC can reflect the early renal damage of HDP patients sensitively and accurately.