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胃癌前病变的研究,对于胃癌的早期发现和预防有重要意义。但由于进行系统性研究的时间还比较短,目前对胃癌前病变的认识还很不深入和全面,在有些问题上的观点还不统一。本文仅就这方面的进展情况和存在问题,作一简要介绍和讨论。癌前病变是指具有高度潜在恶变倾向的病理改变。正常胃粘膜的组织结构比较复杂,含有若干类型的上皮细胞。因而胃癌及其癌前病变的组织学也相应比较复杂,不象被复鳞状上皮的器官那样单纯。迄今,对胃癌前病变的研究,比较集中于胃粘膜的异型增生(dysplasia)和肠上皮化生。但胃癌的癌前
The study of gastric precancerous lesions is of great significance for the early detection and prevention of gastric cancer. However, due to the relatively short time for systematic research, the current understanding of gastric precancerous lesions is not very thorough and comprehensive, and the views on some issues are not uniform. This article only briefly introduces and discusses the progress and problems in this area. Precancerous lesions are pathological changes that have a high potential for malignant transformation. The structure of normal gastric mucosa is more complex and contains several types of epithelial cells. Therefore, the histology of gastric cancer and its precancerous lesions is correspondingly complex, not as simple as the organs of the complex squamous epithelium. To date, studies of gastric precancerous lesions have focused more on gastric dysplasia and intestinal metaplasia. But before the cancer,