非甾体抗炎药 (NSAIDs)不仅引起胃十二指肠损害 ,还可引起小肠和大肠损害。NSAIDs小肠损害包括溃疡、穿孔、狭窄及NSAIDs肠病 ,以后者最为常见 ,表现为肠道失血、蛋白丢失及回肠吸收功能障碍。NSAIDs大肠损害包括非特异性结肠炎、溃疡、穿孔、狭窄 ,还可使原有结肠病变加重。其肠损害机制前期可能与NSAIDs抑制环氧合酶和线粒体氧化磷酸化 ,引起粘膜防御能力降低有关 ,后期则与肠腔内侵袭因素的作用有关。目前尚无有效的治疗方法 ,寻求副作用少的新型NSAIDs将可预防肠道损害的发生。 Non-steroidal anti-inflammatory drugs (NSAIDs) not only cause gastroduodenal damage, but also cause damage to the small intestine and large intestine. Small bowel lesions of NSAIDs include ulceration, perforation, stenosis and NSAIDs enteropathy, the latter being the most common manifestations of intestinal hemorrhage, loss of protein and ileal absorption dysfunction. Large intestinal damage NSAIDs including non-specific colitis, ulcers, perforation, stenosis, but also make the original colon disease increased. The mechanism of intestinal damage may be related to NSAIDs inhibition of cyclooxygenase and mitochondrial oxidative phosphorylation, causing decreased mucosal defense capacity, the latter part of the intestine with the role of invasion factors. There is currently no effective treatment, looking for fewer side effects of new NSAIDs will prevent the occurrence of intestinal damage.