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目的研究分析胸腔内注入顺铂联合干扰素治疗恶性胸腔积液的临床疗效。方法病理确诊的恶性胸腔积液106例。经胸腔插管引流术排尽胸液后,按随机化原则分成两组,治疗组(56例)在胸腔内注入DDP40mg/m2,干扰素400万U。对照组(50例)在胸腔内注入DDP40mg/m2。一周后重复一次,观察疗效、生活质量以及毒副反应。结果治疗组总有效率78%,较对照组52%差异有统计学意义(P<0.05)。Kamofsky评分>70分,治疗组较对照组有显著提高(P<0.05)。结论胸腔内注入顺铂联合干扰素治疗恶性胸腔积液是一种有效的、不良反应小、可耐受的方法。
Objective To study the clinical efficacy of intrapleural injection of cisplatin combined with interferon in the treatment of malignant pleural effusion. Methods 106 cases of pathologically confirmed malignant pleural effusion. Thoracic drainage after pleural effusion drainage, according to the principle of randomized into two groups, the treatment group (56 cases) in the thoracic cavity injection of DDP40mg / m2, interferon 4 million U.. Control group (50 cases) in the thoracic cavity injection of DDP40mg / m2. Repeat after a week to observe the efficacy, quality of life and side effects. Results The total effective rate in the treatment group was 78%, which was significantly higher than that in the control group (52%) (P <0.05). Kamofsky score> 70 points, the treatment group than the control group increased significantly (P <0.05). Conclusion Intrathoracic injection of cisplatin combined with interferon in the treatment of malignant pleural effusion is an effective method with small adverse reactions and tolerability.