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首次采用疫苗治疗转移性乳腺癌的临床经验 ,已在美国北卡罗莱纳州大学（ＵＮＣ）Ｌｉｎｅｂｅｒｇｅｒ癌症综合治疗中心展开。疫苗是通过将树突状细胞与ＨＥＲ２／Ｎｅｕ蛋白片段联结制造的 ,人们在研究如何提高Ｔ淋巴细胞杀伤癌细胞的反应性时发现 ,在乳腺癌细胞上存在ＨＥＲ
The first clinical experience with vaccines for metastatic breast cancer has been performed at the University of North Carolina at the Lineberger Cancer Comprehensive Therapy Center. The vaccine was made by linking dendritic cells with HER2/Neu protein fragments. People were studying how to increase the reactivity of T lymphocytes to kill cancer cells and found that HER cells exist on breast cancer cells.