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肺癌患者血清LDH和LDH同工酶的阳性率分别为55.5％和60％。血清LDH同工酶主要表现LDH_3增高和LDH_1降低。肺癌组织LDH活力增高,LDH_1、LDH_2降低,LDH_4增高,向M型酶谱转移。癌性胸水LDH活力大于同一患者的血清LDH,肝硬化腹水LDH活力于同一患者的血清LDH。癌性胸水的LDH_4高达55％,肝硬化腹水的同工酶谱与同一患者的血清相近,结核性胸水呈中间型酶谱。据此,检测血清、胸水和组织LDH和LDH同工酶对肺癌的诊断有一定价值。
The positive rates of serum LDH and LDH isozymes in lung cancer patients were 55.5% and 60%, respectively. The serum LDH isoenzymes mainly showed an increase in LDH_3 and a decrease in LDH_1. LDH activity in lung cancer tissue increased, LDH_1, LDH_2 decreased, LDH_4 increased, and shifted to M-type zymogram. The LDH activity of cancerous pleural effusion is greater than that of the same patient, and the LDH activity of cirrhotic ascitic fluid is the serum LDH of the same patient. The LDH_4 of malignant pleural effusion is as high as 55%. The isoenzyme spectrum of cirrhosis ascites is similar to the serum of the same patient. Tuberculous pleural effusion is an intermediate zymogram. Based on this, serum, pleural effusion, and tissue LDH and LDH isoenzymes have a certain value in the diagnosis of lung cancer.