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为开发灵芝的保健功能 ,对灵芝水提取液的抗突变作用进行了研究。用小鼠骨髓细胞微核试验、小鼠睾丸染色体畸变试验和体外哺乳动物细胞 (V79 HGPRT)试验对灵芝水提取液的抗突变作用进行评价。结果显示 ,灵芝水提取液对环磷酰胺诱导的小鼠骨细胞微核发生率有明显的抑制作用 ,与对照组相比差异有显著性 (P <0 0 1) ;对丝裂霉素诱导的中国仓鼠V79细胞的基因突变有抑制作用 ,与对照组相比 ,中、高剂量组的差异均有显著性 (P <0 0 1) ;对环磷酰胺诱导的小鼠睾丸细胞染色体畸变无明显影响。在本试验条件下 ,灵芝水提取液有一定的抗突变作用
In order to develop the health functions of Ganoderma lucidum, the antimutagenicity of Ganoderma lucidum water extract was studied. Micronucleus test of mouse bone marrow cells, chromosome aberration test of mouse testis and in vitro mammalian cell (V79 HGPRT) test were used to evaluate the antimutagenic effect of Ganoderma lucidum water extract. The results showed that Ganoderma lucidum aqueous extract significantly inhibited the occurrence of micronucleus in mouse bone cells induced by cyclophosphamide, compared with the control group, the difference was significant (P <0 01); induction of mitomycin The gene mutations of Chinese hamster V79 cells were inhibited. Compared with the control group, the difference between the high dose group and the high dose group was significant (P < 0 01). There was no chromosome aberration induced by cyclophosphamide in mouse testicular cells. Obvious effect. Under the conditions of this experiment, Ganoderma lucidum water extract has certain antimutagenic effect