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结直肠癌是我国常见的消化道恶性肿瘤。目前认为结直肠癌的形成是一个多因素、多步骤的过程,其具体发病机制尚不清楚。microRNA是一类非编码小分子RNA,能在转录后水平调控靶基因的表达,参与肿瘤的增殖、侵袭和转移,甚至调节肿瘤化疗敏感性。学者普遍认为mircroRNA-203(mir-203)是抗癌小分子RNA,但与以往不同的是mir-203在结直肠癌肿的表达水平仍存在争议。本文将概述mir-203在结直肠癌的发生、发展、诊断、预后以及药物抗性中发挥的各类生物学作用。阐述mir-203在结直肠癌不同信号通路中的作用,探索其在结直肠癌研究中的全部潜能。
Colorectal cancer is a common gastrointestinal cancer in China. At present, the formation of colorectal cancer is a multi-factor and multi-step process, and its specific pathogenesis is not yet clear. MicroRNA is a type of non-coding small RNA that regulates the expression of target genes at the post-transcriptional level, participates in the proliferation, invasion and metastasis of tumors, and even regulates the chemotherapy sensitivity of tumors. Scholars generally believe that mircroRNA-203 (mir-203) is an anti-cancer small molecule RNA. However, unlike previous studies, the expression level of mir-203 in colorectal cancer is still controversial. This article will outline the various biological roles of mir-203 in the occurrence, development, diagnosis, prognosis, and drug resistance of colorectal cancer. Explain the role of mir-203 in different signaling pathways of colorectal cancer and explore its full potential in colorectal cancer research.