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(六)胰升糖素:1921年Banting和Best在成功地分离胰岛素时,发现在胰腺提取物的作用中,早期时相里出现一个短暂的高血糖阶段,然后才出现胰岛素的低血糖作用。1923年Collip和Murlin认为这种致高血糖作用是来源于另一种升糖物质,命名为高血糖素。1957年Bromer等研究出猪胰高血糖素的一级结构,搞清了它们的氨基酸排列顺序;并在1971年又把牛胰高血糖素的一级结构弄清,发现两者完全相同。1971年Sundby及Marknssen二氏又证明人类胰高血糖素的一级结构也和前两者一致。
(VI) Glucagon: In 1921, Banting and Best successfully isolated insulin and found that in the role of pancreatic extract, early phase appeared in a short period of hyperglycemia, and then the role of insulin hypoglycemia. 1923 Collip and Murlin that this role in hyperglycemia is derived from another sugar substance, named glucagon. In 1957, Bromer et al. Studied the primary structure of porcine glucagon and figured out their amino acid sequence. In 1971, the primary structure of bovine glucagon was found again and the two were identical. In 1971, Sundby and Markenssen II proved that the primary structure of human glucagon is also consistent with the former two.