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用葡萄糖氧化酶法放射免疫法分别检测５０例急性白血病患者胰岛β细胞功能，以阐明糖代谢障碍机制及其对治疗的影响。１４例治疗前口服葡萄糖耐量试验（ＯＧＴＴ）呈糖尿病曲线，胰岛素和Ｃ肽释放延迟，治疗后６例恢复正常。５例治疗前糖耐量减低，胰岛素和Ｃ肽释放减少，治疗后恢复。５例治疗前的ＯＧＴＴ等正常，治疗后糖耐量减低，胰岛素和Ｃ肽释放减少。１６例治疗前后ＯＧＴＴ等正常。５０例抗胰岛素抗体阴性。４７例检测了红细胞胰岛素受体结合率均明显高于正常对照（Ｐ＜０．００１）。
Glucose oxidase method radioimmunoassay were used to detect the function of islet β cells in 50 patients with acute leukemia in order to clarify the mechanism of glucose metabolism disorder and its impact on the treatment. Oral glucose tolerance test (OGTT) showed a curve of diabetes, delayed release of insulin and C peptide in 14 patients before treatment, and 6 returned to normal after treatment. 5 cases before treatment, decreased glucose tolerance, insulin and C-peptide release reduced after treatment. 5 cases of normal OGTT before treatment, after treatment, decreased glucose tolerance, insulin and C-peptide release decreased. OGTT was normal before and after treatment in 16 cases. 50 cases of anti-insulin antibodies negative. 47 cases detected erythrocyte insulin receptor binding rate were significantly higher than the normal control (P <0.001).