Neural electrodes,the core component of neural prostheses,are usually encapsulated in polydimethylsiloxane(PDMS).However,PDMS can generate a tissue response after implantation.Based on the physicochemical properties and excellent biocompatibility of polyurethane(PU)and poly(vinyl alcohol)(PVA)when used as coating materials,we synthesized PU/PVA hydrogel coatings and coated the surface of PDMS using plasma treatment,and the cytocompatibility to rat pheochromocytoma(PC12)cells was assessed.Protein adsorption tests indicated that the amount of protein adsorption onto the PDMS substrate was reduced by 92%after coating with the hydrogel.Moreover,the PC12 cells on the PU/PVA-coated PDMS showed higher cell density and longer and more numerous neurites than those on the uncoated PDMS.These results indicate that the PU/PVA hydrogel is cytocompatible and a promising coating material for neural electrodes to improve their biocompatibility. Neural electrodes, the core component of neural prostheses, are usually encapsulated in polydimethylsiloxane (PDMS). However, PDMS can generate a tissue response after the implantation. Based on the physicochemical properties and excellent biocompatibility of polyurethane (PU) and poly (vinyl alcohol) ( PVA) when used as coating materials, we synthesized PU / PVA hydrogel coatings and coated the surface of PDMS using plasma treatment, and the cytocompatibility to rat pheochromocytoma (PC12) cells was assessed. Protein adsorption tests indicated that the amount of protein adsorption onto the PDMS substrate was reduced by 92% after coating with the hydrogel. Moreover, the PC12 cells on the PU / PVA-coated PDMS showed higher cell density and longer and more numerous neurites than those on the uncoated PDMS. The results show that the PU / PVA hydrogel is cytocompatible and a promising coating material for neural electrodes to improve their biocompatibility.