论文部分内容阅读
铍肺患者和实验性铍中毒动物均有血糖调节障碍现象。血糖的调节有赖于激素、神经和酶的作用。我们已往的工作证明,中毒时血糖调节的失常与肾上腺素,胰岛素和肾上腺皮质激素无关。已证明铍离子在体外抑制淀粉酶,磷酸葡萄糖变位酶和磷酸甘油醛脱氢酶的活性。至于这些酶的变化与血糖调节障碍的关系如何,尚不清楚。本文研究了铍中毒大鼠体内与糖代谢有关酶的活性。
Beryllium lung patients and experimental beryllium poisoning animals have disorders of blood glucose regulation. The regulation of blood glucose depends on the role of hormones, nerves and enzymes. Our past work has shown that the disorders of glucose regulation during poisoning are not related to adrenaline, insulin and adrenocorticotropic hormone. Beryllium ion has been shown to inhibit the activity of amylase, phosphoglucomutase and glycerophosphate phosphate dehydrogenase in vitro. As for the relationship between changes in these enzymes and impaired glucose regulation, it is unclear. In this paper, beryllium poisoning rats with glucose metabolism related enzymes activity.