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Background Previous studies indicate that CD43 plays a role in regulating the adhesion of lymphocytes,cell mutation and activation,however,little is known about its effect on systemic lupus erythematousus (SLE).This study was designed to explore the clinical significance of CD43 in SLE patients.@@Methods We used microarray and real-time PCR to detect the mRNA and protein expression of magnetic bead sorted T cells and B cells from peripheral blood mononuclear cells (PBMCs) of SLE patients,and analyzed the relationship between CD43 and the clinical indexes.@@Results Both microarray and real-time PCR results showed that CD43 mRNA was significantly decreased in PBMCs of SLE patients compared with healthy controls (P