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作者试图研究实验性心肌梗塞后心肌纤维化和血浆、心肌内羟脯氨酸(HOP)的改变。并且测定了25例原发性心肌病,15例急性心肌梗塞(AMI)、14例陈旧性心肌梗塞(OMI)、14例冠心病心绞痛、10例心肌炎后心律失常、4例急性心包炎患者的血浆HOP浓度。20例正常人血浆HOP浓度为5.2～7.9微克/毫升(6.8±0.78)。持发性梗阻型肥厚性心肌病患者血浆HOP浓度较高。AMI患者于发病一周时,血浆HOP开始升高,二周时达高峰。心绞痛和OMI患者血浆HOP轻度升高。急性心色炎患者血浆HOP明显增高。最后作者讨论了血浆HOP测定对心血管疾病诊断的辅助价值。
The authors attempted to study myocardial fibrosis and changes in plasma and myocardial hydroxyproline (HOP) after experimental myocardial infarction. And 25 patients with primary cardiomyopathy, 15 patients with acute myocardial infarction (AMI), 14 patients with old myocardial infarction (OMI), 14 patients with coronary heart disease angina, 10 patients with myocarditis arrhythmia, 4 patients with acute pericarditis Plasma HOP concentration. Plasma HOP concentrations in 20 normal subjects ranged from 5.2 to 7.9 μg / mL (6.8 ± 0.78). Patients with obstructive hypertrophic cardiomyopathy plasma HOP concentrations higher. One week after the onset of AMI, plasma HOP began to rise and peaked at two weeks. Angina and OMI plasma HOP slightly elevated. Patients with acute myocarditis HOP plasma was significantly higher. Finally, the authors discuss the value of plasma HOP in the diagnosis of cardiovascular disease.