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目的利用我国青少年锁骨胸骨端骨骺发育变化规律,探讨CT容积再现(volume rendering,VR)数据与生物学年龄的相关性,并建立推断骨龄的数学模型。方法通过对我国华东、华南地区684名15~25周岁青少年双侧锁骨胸骨端进行CT薄层扫描并VR三维图像重组,测量并计算双侧锁骨胸骨端骨骺最长径、干骺端最长径及其长度比、骨骺面积、干骺端面积及其面积比等数据,并建立骨龄推断的数学模型。再将50例训练样本代入数学模型,检验模型的准确性。结果左、右两侧骨骺与干骺端长度比、面积比在同一年龄组男女性间差异具有统计学意义(P<0.05)。建立的数学模型表明锁骨胸骨端骨骼的发育规律与生物学年龄具有高度的相关性,所有模型的准确率都高于70.5%(±1.0岁)和82.5%(±1.5岁)。结论建立的骨龄数学模型的可操作性强、准确性较高。这不仅可与图谱法相互印证和支持,提高骨龄推断的准确性;同时,该方法对未来研究其他单一部位骨龄推断具有重要的意义。
Objective To explore the relationship between volume rendering (CT) volume rendering and biological age in the development of clavicle and sternal epiphysis in our country and to establish a mathematical model to infer the bone age. Methods The CT images of 684 adolescents aged 15-25 years old in East China and South China were obtained by CT scanning and three-dimensional VR image reconstruction. The maximal diameter of the epiphysis and the longest diameter of the metaphysis were measured and calculated. And its length ratio, epiphyseal area, metaphyseal area and its area ratio and other data, and establish a mathematical model of bone age inference. Then 50 cases of training samples into the mathematical model to test the accuracy of the model. Results The ratios of epiphysis to metaphysis length and area ratio on the left and right sides were statistically significant (P <0.05) in the same age group. The established mathematical model shows that the development of the sternum of the clavicle has a high correlation with the biological age. The accuracy of all the models is higher than 70.5% (± 1.0 years) and 82.5% (± 1.5 years). Conclusion The mathematical model of bone age established has strong operability and high accuracy. This not only confirms and supports the mapping method and enhances the accuracy of estimating bone age. At the same time, this method is of great significance for the future study of bone age estimation of other single parts.