儿童难治性肾病 (以下简称ＲＮＳ)是指经强的松标准疗程治疗无效或经强的松治疗有效 ,但频繁复发的原发性肾病综合征。目前西医常用激素和细胞毒性药物治疗 ,近期疗效较好 ,但易复发并有副作用。笔者依据曾章超主任医师的经验 ,结合自己临床体会 ,对提高ＲＮＳ中西医结合疗效思 Children with refractory kidney disease (hereinafter referred to as RNS) refers to the standard treatment by prednisone ineffective or prednisone effective, but frequent recurrent primary nephrotic syndrome. Western medicine currently used hormones and cytotoxic drugs, the recent good effect, but easy to relapse and have side effects. The author based on the experience of Zha Zhangchao, chief physician, combined with their own clinical experience, to improve the efficacy of traditional Chinese and Western medicine RNS thinking