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目的探讨老年2型糖尿病患者采用重组甘精胰岛素联合阿卡波糖治疗的临床疗效。方法将100例老年2型糖尿病患者按就诊顺序编号分为对照组和观察组,每组50例。对照组给予预混胰岛素进行治疗,观察组联用重组甘精胰岛素与阿卡波糖治疗,比较两组患者的空腹血糖(FBG)、餐后2 h血糖(2hBG)、糖化血红蛋白(HbA1c)、体质量指数(BMI)、平均血糖(MBG)、血糖变异系数(CV)以及血糖波动幅度(MAGE)等各项指标的变化情况。结果经治疗后,两组患者的FBG、2 hBG、HbA1c以及MBG均明显下降,比较差异均具有统计学意义(P<0.05);观察组患者的CV和MAGE明显低于对照组,比较差异具有统计学意义(P<0.05)。结论联用重组甘精胰岛素与阿卡波糖治疗老年2型糖尿病降糖效果较好,安全性也较高,值得临床借鉴和推广。
Objective To investigate the clinical efficacy of recombinant glargine plus acarbose in elderly type 2 diabetic patients. Methods One hundred cases of type 2 diabetes mellitus were divided into control group and observation group according to the order of visiting doctor, with 50 cases in each group. The control group was treated with premixed insulin. The observation group was treated with recombinant insulin glargine and acarbose. The fasting blood glucose (FBG), postprandial blood glucose (2hBG), hemoglobin A1c (HbA1c) BMI, MBG, CV, and MAGE were measured. Results After treatment, FBG, 2 hBG, HbA1c and MBG in both groups were significantly decreased (all P <0.05), while CV and MAGE in observation group were significantly lower than those in control group Statistical significance (P <0.05). Conclusions Combination of recombinant insulin glargine and acarbose treatment of elderly type 2 diabetes better hypoglycemic effect, safety is also high, it is worth clinical reference and promotion.