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目的探讨肺炎球菌疫苗与流感疫苗联合接种对反复呼吸道感染(RRTI)患儿健康相关生活质量(HRQOL)的影响。方法选取2010年1月-2013年6月间来该院儿科门诊及住院治疗的RRTI患儿124例,单盲法随机分为观察组和对照组,每组各62例。观察组给予肺炎球菌疫苗与流感疫苗联合接种;对照组在研究期间不接种任何疫苗。观察两组患儿的RRTI相关临床指标,分别于接种前、接种后14个月和26个月时采用儿科健康相关生活质量普适性核心量表4.0(Peds QLTM4.0)评估两组患儿的生活质量。结果观察组患儿呼吸道感染次数、发热次数、抗生素使用时间、总治疗花费均低于对照组,差异均有统计学意义(t值分别为5.946、7.574、6.980、10.147,均P<0.05)。接种前两组患儿Peds QLTM4.0评分之间差异无统计学意义(t=0.021,P>0.05);接种后相同时间点观察组患儿Peds QLTM4.0总分和各维度评分均明显高于对照组患儿,差异有统计学意义(t值分别为7.697、5.034、5.510、6.641、5.924,均P<0.05);随着接种时间的延长,观察组患儿Peds QLTM4.0总分和各维度评分均较前一时间点明显提升,差异有统计学意义(t值分别为6.631、6.095、7.214、5.914、6.632,均P<0.05)。结论肺炎球菌疫苗与流感疫苗联合接种可有效控制RRTI患儿病情,改善HRQOL,保证RRTI患儿健康成长。
Objective To investigate the effect of combination of pneumococcal vaccine and influenza vaccine on health-related quality of life (HRQOL) in children with recurrent respiratory tract infection (RRTI). Methods A total of 124 RRTI patients from January 2010 to June 2013 in pediatric outpatient department and inpatient hospital were selected and randomly divided into observation group and control group with 62 cases in each group. The observation group was given pneumococcal vaccine in combination with influenza vaccine; the control group did not receive any vaccine during the study period. The RRTI-related clinical indicators were observed in two groups of children with pre-vaccination, 14 and 26 months after inoculation using pediatric health-related quality of life universal core scale 4.0 (Peds QLTM4.0) to assess the two groups of children The quality of life Results The number of respiratory infections, the frequency of fever, the duration of antibiotics use and the total cost of treatment in the observation group were all lower than those in the control group (t = 5.946, 7.574, 6.980 and 10.147, all P <0.05). There was no significant difference in Peds QLTM 4.0 between the two groups before vaccination (t = 0.021, P> 0.05). At the same time point after vaccination, the scores of Peds QLTM 4.0 in each group were significantly higher In the control group, the difference was statistically significant (t = 7.697,5.034,5.510,6.641,5.924, all P <0.05). With the prolongation of inoculation time, the total score of Peds QLTM 4.0 in the observation group and The score of each dimension was significantly higher than the previous time point, the difference was statistically significant (t values were 6.631,6.095,7.214,5.914,6.632, both P <0.05). Conclusions The combination of pneumococcal vaccine and influenza vaccine can effectively control the condition of RRTI children, improve HRQOL and ensure the healthy growth of RRTI children.