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目的:评价妊娠早期妇女的性激素水平与先兆流产的关系,为临床的早期诊疗方案提供依据。方法:选择从2013年9月至2015年9月于温州市中医院妇产科就诊检查的206例妊娠周期为4~12周的孕妇,其中诊断为先兆流产的妊娠孕妇103例,余103例孕妇为正常妊娠体检者。另依据随访妊娠孕周的不同,分为3个亚组(4周以内,4~8周,8~12周)。采用化学荧光法测定不同亚组内正常妊娠体检者及先兆流产妊娠孕妇的各项性激素指标情况,并进行统计学分析。结果:随着妊娠孕周的增加,两组孕妇的HCG均显著升高,其中在妊娠4周以内和妊娠4~8周,两组孕妇的HCG比较(P>0.05),但在妊娠8周以上的孕妇间,先兆流产孕妇组孕妇的HCG显著低于正常孕妇组(P<0.05),E2随着妊娠孕周的增加逐渐升高,但是从妊娠4周以内、妊娠4~8周及妊娠8周以上的孕妇间的E2比较,其中先兆流产孕妇组的E2表达水平均显著低于正常组孕妇(P<0.05),两组孕妇P指标表达水平随着妊娠孕周的增长而增加,但是各组间比较(P<0.05),其中先兆流产孕妇组的P水平均显著低于正常孕妇组。结论:妊娠早期妇女的三项重要性激素指标均有变化,对先兆流产的早期判断均有意义。
Objective: To evaluate the relationship between sex hormones and threatened abortion in early pregnancy, and provide the basis for clinical diagnosis and treatment. Methods: From September 2013 to September 2015 in Wenzhou City Hospital Obstetrics and Gynecology examination of 206 pregnant women with a pregnancy cycle of 4 to 12 weeks of pregnant women, including the diagnosis of threatened abortion pregnant women in 103 cases, 103 cases Pregnant women for normal pregnancy test. According to the different gestational weeks of follow-up, divided into three subgroups (4 weeks, 4 to 8 weeks, 8 to 12 weeks). The levels of sex hormones in different subgroups of normal pregnant women and threatened abortion pregnant women were determined by chemiluminescence method and statistically analyzed. Results: With the increase of gestational age, the HCG in both groups increased significantly, and within 4 weeks of gestation and 4 to 8 weeks of gestation, the HCG levels of the two groups were significantly different (P> 0.05) Among the above pregnant women, the HCG of pregnant women in threatened abortion group was significantly lower than that of normal pregnant women (P <0.05), E2 increased gradually with the increase of gestational age, but within 4 weeks of gestation, 4 to 8 weeks of gestation and pregnancy E2 levels of pregnant women more than 8 weeks, in which threatened abortion pregnant women group E2 expression levels were significantly lower than the normal pregnant women (P <0.05), P indicators in both groups of pregnant women with gestational gestational weeks increased, but The levels of P in threatened abortion group were significantly lower than those in normal pregnant group (P <0.05). CONCLUSIONS: The three important hormonal indices of women in the first trimester of pregnancy both have changes and are of significance in the early judgment of threatened abortion.