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目的观察颅内外动脉狭窄患者血管内支架成形术前后血清超敏C反应蛋白(hs-CRP)水平的变化。方法对25例接受血管内支架成形术的颅内外动脉狭窄患者术前、术后3d及术后6～12个月的血清hs-CRP水平进行检测,并对术后6～12个月血管再狭窄及无再狭窄患者的hs-CRP水平进行比较。结果25例颅内外动脉狭窄患者血管内支架成形术后3d及术后6～12个月的血清hs-CRP水平均明显高于术前(均P<0.05),术后3d血清hs-CRP水平与术后6～12个月比较差异无统计学意义(P>0.05);再狭窄组术后6～12个月时血清hs-CRP水平明显高于无再狭窄组(P<0.05)。结论颅内外动脉狭窄患者血管内支架成形术后血清hs-CRP水平增高,出现术后血管再狭窄的患者升高更显著。
Objective To observe the changes of serum hs-CRP levels before and after endovascular stent stenosis in patients with intracranial and extracranial arterial stenosis. Methods Serum levels of hs-CRP were measured in 25 patients with intracranial and extracranial arterial stenosis undergoing endovascular stenting before operation, 3 days after operation and 6 to 12 months after operation. The level of hs-CRP in patients with stenosis and without restenosis was compared. Results Serum hs-CRP levels in 25 patients with intracranial and extracranial arterial stenosis were significantly higher than those preoperatively (all P <0.05) 3d after operation and 6-12 months after operation. The levels of hs-CRP (P> 0.05). The level of hs-CRP in restenosis group was significantly higher than that in non-restenosis group (P <0.05) at 6-12 months postoperatively. Conclusion The level of hs-CRP in patients with intracranial and extracranial arterial stenosis increased after stenting, and the patients with postoperative vascular restenosis increased more significantly.